Artemisinin drug resistance and monitoring: a narrative review

Artemisinin drug resistance is one of the major reasons for malaria treatment failures in sub-Saharan African countries where artemisinin-based combination therapy (ACT) first-line uncomplicated malaria. The occurrence single nucleotide polymorphisms (SNPs) found to correlate with antimalarial resistance. With artemisinin, SNPs occurs at Kelch 13-propeller gene locus on chromosome 13. artemisinin surveillance strategy involves continuous monitoring biomarker detect emergence mutations which could herald region. In this narrative review paper, we examined existing literature bridge knowledge gap and accentuate importance routine Africa. We conducted our search PubMed database Google Scholar identify peer-reviewed articles, reports, abstracts using following keywords; ‘artemisinin resistance’, ‘antimalarial ‘artemisinin-based therapy’, ‘Kelch 13-propeller’, ‘K13- propeller gene’, ‘K13 molecular marker’. provided pertinent information derivatives, therapy, action definition resistance, genetic basis discovery 13, surveillance. Molecular can provide healthcare policy makers a forecast impending threats treatment. This more so when drugs are instance, give hint that failing despite fact combination, it still apparently clinically effective.